Super NAD
NMN + Methylcobalamin
Two actives in a single lyophilized vial, formulated for subcutaneous research use on a three-times-weekly schedule. Revised July 2026: direct NAD+ was removed and the NMN load increased.
Why Everything Else Is Getting It Wrong
The NAD+ supplement market is built on three compounding misconceptions. Here's what they're not telling you.
❌ Injecting NAD+ Directly Doesn't Work
NAD+ is too large and too charged to cross cell membranes. Injected NAD+ is degraded extracellularly to nicotinamide within minutes. IV NAD+ clinics charging $400–800 per session are selling you a nicotinamide flush — not NAD+ delivery. The "energy and clarity" you feel is a niacin surge, not cellular NAD+ restoration.
❌ Oral NMN Wastes 70% of Every Dose
Oral NMN faces gut enzyme degradation, hepatic first-pass metabolism, and intestinal conversion to NR and nicotinamide before it ever reaches your tissues. Studies confirm only 25–30% bioavailability. You're paying for 500mg and getting 125mg. Every single day.
❌ Nobody Addresses the Methyl Drain
High-dose NMN supplementation activates sirtuins, which generates nicotinamide as a byproduct. Clearing that nicotinamide consumes SAM — your body's universal methyl donor. Sustained NMN without methyl support depletes methylation capacity, raises homocysteine, and undermines the very longevity pathways you're trying to activate.
Two Actives. One Vial.
67mg × 6 doses
750mcg × 6 doses
Draw 0.42mL — ~42 units on a U-100 syringe
3× weekly (Mon / Wed / Fri) · 2 vials per month
- NMN — 67 mg per doseAn immediate NAD+ precursor. Research describes NMN as entering cells via the Slc12a8 transporter, and reports subcutaneous delivery as avoiding the gut degradation and first-pass metabolism that the literature associates with limited oral bioavailability.
- Methylcobalamin — 750 mcg per doseThe bioactive form of B12 and a methyl donor for the methionine cycle. Published work describes NMN metabolism as consuming methyl groups, and stability studies report methylcobalamin stability peaking near pH 5 — which is where this formulation is held.
- Direct NAD+ removed — July 2026Earlier versions included NAD+ disodium. It was dropped in favour of a higher NMN load: research describes NMN converting to NAD+ in vivo via NMNAT, and removing direct NAD+ also removes its pH sensitivity from the formulation.
- Clear glass in a light-blocking case, sealed under argonMethylcobalamin is severely photolabile, so light protection is not optional — but it comes from the case rather than the glass. We would rather you could see the cake you paid for and keep it in the case between doses than hide it behind amber. The vial is sealed under argon to protect B12 from oxidation across shelf life.
Why SubQ NMN Outperforms Everything Else
Every claim we make is anchored to primary literature. Here's the mechanism behind each compound.
NAD+ biosynthesis requires NAMPT — an enzyme that declines significantly with age. NMN bypasses the upstream steps that NAMPT controls, entering the pathway downstream and restoring NAD+ even when NAMPT activity has collapsed in aged tissues.
NMN enters cells via the Slc12a8 transporter confirmed in a 2019 Nature Metabolism study. This is a direct transport mechanism — NMN doesn't need to be converted extracellularly before cellular uptake. SubQ injection delivers intact NMN directly to this transporter.
NAD+ is the substrate for sirtuins (SIRT1–7) — the longevity enzymes that regulate DNA repair, mitochondrial biogenesis, inflammation, and metabolic efficiency. You can't activate sirtuins without NAD+. Restoring NAD+ to youthful levels is the mechanism, not the endpoint.
CD38 is an enzyme that degrades NAD+ and rises with age and inflammation. It's the primary driver of age-related NAD+ decline. A 2016 Cell Metabolism study showed CD38 knockout mice maintain elevated NAD+ with age. Oral apigenin (50mg daily) is the practical CD38 inhibitor that makes every injection go further.
Sirtuin activation generates nicotinamide. Clearing nicotinamide via NNMT consumes SAM — your body's methyl donor. Without replenishment, sustained NMN supplementation can deplete methylation capacity over time, raise homocysteine, and undermine epigenetic regulation. Methylcobalamin in the vial solves this directly.
Oral NMN bioavailability is estimated at 25–30% due to gut enzyme degradation and hepatic first-pass metabolism. SubQ bypasses both. A 50mg SubQ dose delivers what 150–200mg oral cannot. Human studies at 1g/day oral showed 1.7× blood NAD+ elevation — SubQ achieves comparable elevation at a fraction of the dose.
The Bioavailability Gap Is Not Small
This isn't a marginal difference. Oral NMN loses the majority of every dose before it reaches your tissues.
- Gut enzymes convert NMN to NR and nicotinamide before absorption
- Portal circulation delivers straight to liver — first-pass metabolism consumes a significant fraction
- ~25–30% estimated bioavailability — you're paying for 500mg, getting ~130mg
- Absorption varies with food, gut motility, and individual enzyme expression
- Inconsistent dose response — you never know what actually reached your tissues
- Gut microbiome consumes some NMN before absorption
- Bypasses gut entirely — no enzymatic degradation before systemic circulation
- No hepatic first-pass — full dose enters systemic circulation intact
- ~100% bioavailability — 50mg injected is 50mg delivered
- Consistent absorption shot to shot regardless of meals or GI status
- Plasma peak in 15–30 minutes vs 1–2 hours oral
- 50mg SubQ ≈ 150–200mg oral — at a fraction of the cost per effective dose
Why the formula changed
Nothing here is frozen because it is already printed on a label. When the reasoning changes, the formula changes — and we publish what changed and why.
The original blend carried NAD+ disodium alongside NMN, on the reasoning that extracellular cleavage would supply a second, delayed NMN pool. It also carried NAD+'s narrower pH tolerance into the vial.
Injected NAD+ takes the long way round to become the thing you already had. Research describes the NAD+ molecule as too large and too charged to cross the cell membrane intact — so injected NAD+ does not enter cells as NAD+. It is cleaved outside the cell, largely back down to NMN, and it is that NMN which is then transported in and rebuilt into NAD+ by NMNAT enzymes.
Which means injecting NAD+ is a slower, more expensive route to delivering NMN. Every molecule has to be broken down and reassembled before it does anything, and the literature describes losses at each step. Injecting NMN directly skips that entire round trip — it is already the form the transporter accepts and one enzymatic step from NAD+ itself.
Removing NAD+ also removed the component with the tightest pH constraint, allowing the vial to sit at the pH the stability literature associates with peak methylcobalamin stability. Lower cost per milligram of delivered precursor, fewer steps, and a more stable formulation — the same decision three different ways.
The month was split across two vials rather than one. A shorter cake column reconstitutes more readily, and less time in solution after opening means less opportunity for degradation before the last dose is drawn.
Why Every NMN Product Without B12 Is Incomplete
This is the mechanism most supplement companies either don't understand or don't want to explain.
The Methyl Drain Cascade
Methylcobalamin isn't a nice-to-have addition. It's the compound that makes sustained NMN supplementation safe and complete. Here's what injectable B12 does that oral cannot:
- ~100% bioavailability — oral B12 absorption is limited to ~1% at therapeutic doses due to intrinsic factor saturation. Injectable bypasses this entirely.
- Immediate systemic availability — no gut absorption variability, no intrinsic factor dependence, no gastric acid degradation.
- Direct methyl donor — methylcobalamin (not cyanocobalamin) provides the methyl group directly to the methylation cycle without additional conversion steps.
- Homocysteine clearance — B12 is the cofactor for methionine synthase, the enzyme that converts homocysteine back to methionine. Elevated homocysteine is an independent cardiovascular and neurological risk factor.
- Visual QC indicator — the pink/red color of reconstituted Super NAD+ is the methylcobalamin. If the solution is colorless after reconstitution, the B12 has degraded and the vial should be discarded. Color = quality confirmation built in.
Super NAD+ vs. The Alternatives
| IV NAD+ Clinics | Oral NMN Capsules | Super NAD+ SubQ | |
|---|---|---|---|
| Mechanism | NAD+ degraded to NAM before cell entry | NMN degraded in gut, first-pass loss | Direct NMN cellular uptake via Slc12a8 |
| Bioavailability | Low — most NAD+ never enters cells | ~25–30% of dose reaches tissues | ~100% — full dose enters circulation |
| Methyl Support | ✗ None | ✗ None | ✓ Methylcobalamin included |
| Consistency | Variable — session to session | Variable — food, gut motility, enzymes | Consistent — same dose every injection |
| Cost per month | $300–800+ per session | $30–80/month for quality brands | Fraction of clinic cost, superior delivery |
| Lyophilized stability | ✗ IV bag, single use | ✗ N/A | ✓ 18–24 month shelf life frozen |
| Self-administrable | ✗ Clinic only | ✓ Yes | ✓ Simple SubQ — insulin syringe |
The Protocol At A Glance
Common Questions
That's the methylcobalamin (Methyl B12). It's completely normal and expected — in fact it's a quality indicator. At 1.8mg/mL the solution will appear nearly clear to very faint pink — this is normal and correct at this concentration. If the solution is visibly yellow or cloudy, discard.
SubQ injection with a standard U-100 insulin syringe. Draw 0.42mL (~42 units on the syringe). Common sites: abdomen (pinch an inch of fat, inject at 45°), outer thigh, or flank. Rotate sites. Inject 3x/week — Monday, Wednesday, Friday works well. 0.42mL is a comfortable SubQ volume.
Add 3mL of bacteriostatic water through the rubber stopper using a clean needle and syringe. Gently swirl — do not shake. Store the reconstituted vial at 2–8°C, protected from light, and use within the 15-day window (6 doses, three per week). Light matters here: methylcobalamin is severely photolabile, so keep the vial in its case between doses rather than out on the counter.
NAD+ injected alongside NMN creates a dual-wave delivery mechanism. While NMN is absorbed directly via the Slc12a8 transporter (Wave 1), the NAD+ degrades extracellularly to NMN via CD38/CD73 over the next 30–90 minutes (Wave 2), adding a second delayed bolus. The effect is modest (~10–15% additive) but the mechanism is real and the cost is negligible.
For maximum effect: oral apigenin 50–100mg daily (CD38 inhibitor — blocks the enzyme that degrades NAD+, making every injection go further) and trans-resveratrol 200–500mg with a fatty meal (SIRT1 activator — activates the enzymes that NAD+ feeds). These are oral and complementary — they hit completely different mechanisms than what's in the vial.
Freeze at −20°C, protected from light. The lyophilized cake is stable for 18–24 months properly stored. Keep it in its case for light protection — an opaque storage bag or box works equally well for freezer storage. Once reconstituted, refrigerate at 2–8°C and use within 30 days.
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Stop paying clinic prices for inferior delivery. Stop losing 70% of every oral dose. The complete protocol, explained without the marketing fluff.
View Full Protocol Guide →Disclaimer: This content is for informational and research purposes only and does not constitute medical advice. Consult a qualified healthcare provider before beginning any injection protocol. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
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